MK-0941 mesylate( MK0941 )

Catalog No. M10484 CAS No. 1137916-97-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MK-0941 mesylate
Note

Research use only, not for human use.
Brief Description

MK-0941 mesylate (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively.
Description

MK-0941 mesylate (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively; increases insulin secretion by 17-fold and glucose uptake up to 18-fold, respectively, in isolated rat islets of Langerhans and hepatocytes at 10 uM; exhibits strong glucose-lowering activity in rodent models of type 2 diabetes and healthy dogs.Diabetes Phase 2 Discontinued.
In Vitro

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In Vivo

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Synonyms

MK0941
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Glucokinase
Recptor

Glucokinase
Research Area

Metabolic Disease
Indication

Diabetes

CAS Number

1137916-97-2
Formula Weight

556.605
Molecular Formula

C22H28N4O9S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (179.66 mM)
SMILES

CCS(=O)(=O)C1=NC=C(C=C1)OC2=CC(=CC(=C2)C(=O)NC3=NN(C=C3)C)OC(C)CO.CS(=O)(=O)O
Chemical Name

3-((6-(ethylsulfonyl)-3-pyridinyl)oxy)-5-((1S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide mesylate

1. Eiki J, et al. Mol Pharmacol. 2011 Dec;80(6):1156-65. 2. Meininger GE, et al. Diabetes Care. 2011 Dec;34(12):2560-6.

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