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MK-0941 mesylate
CAS No. 1137916-97-2
MK-0941 mesylate( MK0941 )
Catalog No. M10484 CAS No. 1137916-97-2
MK-0941 mesylate (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 196 | In Stock |
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| 25MG | 363 | In Stock |
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| 50MG | 539 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMK-0941 mesylate
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NoteResearch use only, not for human use.
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Brief DescriptionMK-0941 mesylate (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively.
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DescriptionMK-0941 mesylate (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively; increases insulin secretion by 17-fold and glucose uptake up to 18-fold, respectively, in isolated rat islets of Langerhans and hepatocytes at 10 uM; exhibits strong glucose-lowering activity in rodent models of type 2 diabetes and healthy dogs.Diabetes Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMK0941
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetGlucokinase
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RecptorGlucokinase
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number1137916-97-2
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Formula Weight556.605
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Molecular FormulaC22H28N4O9S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (179.66 mM)
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SMILESCCS(=O)(=O)C1=NC=C(C=C1)OC2=CC(=CC(=C2)C(=O)NC3=NN(C=C3)C)OC(C)CO.CS(=O)(=O)O
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Chemical Name3-((6-(ethylsulfonyl)-3-pyridinyl)oxy)-5-((1S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide mesylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Eiki J, et al. Mol Pharmacol. 2011 Dec;80(6):1156-65.
2. Meininger GE, et al. Diabetes Care. 2011 Dec;34(12):2560-6.
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